Methodological Approaches

Our research employs a comprehensive set of methodologies to explore these mechanisms:

• High-Throughput Screening: We use advanced screening techniques, such as CRISPR-based loss- and gain-of-function studies, to identify key factors involved in stress response pathways and their roles in tumor progression.
• Targeted Functional Studies: Focused investigations are conducted to elucidate the mechanisms of action and the functional consequences of specific factors at cellular, tissue, and systemic levels.
• Imaging: We use an array of advanced imaging technologies, including in vivo cell imaging, wide-field and confocal microscopy, and immunofluorescence. Both conventional and AI-assisted image analysis techniques are employed to examine tumor behavior, cellular interactions, and microenvironmental dynamics.
• Integration of Omics Data: We integrate data from (epi)genomics, transcriptomics, and metabolomics of patient-derived datasets generated from in-house tumor biopsies and public repositories. These datasets are analyzed using advanced bioinformatics to uncover molecular pathways and therapeutic targets, linking experimental findings to clinically relevant applications.

For more information, visit the research laboratory on a 3D Virtual Tour