Publikationen

Characteristics of familial pancreatic cancer families with additional colorectal carcinoma
Bettina Lehman, Elvira Matthäi, Norman Gercke, Ulrike W Denzer, Jens Figiel, Timo Hess, Emily P Slater, Detlef K Bartsch

Fam Cancer. 2023 Jul;22(3):323-330. doi: 10.1007/s10689-023-00328-1. Epub 2023 Jan 31.  https://doi.org/10.1007/s10689-023-00328-1

Proteomics biomarker discovery for individualized prevention of familial pancreatic cancer using statistical learning
Chung Shing Rex Ha, Martina Müller-Nurasyid, Agnese Petrera, Stefanie M Hauck, Federico Marini, Detlef K Bartsch, Emily P Slater, Konstantin Strauch 

PLoS One. 2023 Jan 26;18(1):e0280399. doi: 10.1371/journal.pone.0280399. eCollection 2023.  https://doi.org/10.1371/journal.pone.0280399

Timeline of Development of Pancreatic Cancer and Implications for Successful Early Detection in High-Risk Individuals
Kasper A Overbeek, Michael G Goggins, Mohamad Dbouk, Iris J M Levink, Brechtje D M Koopmann, Miguel Chuidian, Ingrid C A W Konings, Salvatore Paiella, Julie Earl, Paul Fockens, Thomas M Gress, Margreet G E M Ausems, Jan-Werner Poley, Nirav C Thosani, Elizabeth Half, Jesse Lachter, Elena M Stoffel, Richard S Kwon, Alina Stoita, Fay Kastrinos, Aimee L Lucas, Sapna Syngal, Randall E Brand, Amitabh Chak, Alfredo Carrato, Frank P Vleggaar, Detlef K Bartsch, Jeanin E van Hooft, Djuna L Cahen, Marcia Irene Canto, Marco J Bruno; International Cancer of the Pancreas Screening Consortium

Gastroenterology. 2022 Mar;162(3):772-785.e4. doi: 10.1053/j.gastro.2021.10.014. Epub 2021 Oct 19.https://doi.org/10.1053/j.gastro.2021.10.014

Combinations of Low-Frequency Genetic Variants Might Predispose to Familial Pancreatic Cancer
Emily P Slater, Lisa M Wilke, Lutz Benedikt Böhm, Konstantin Strauch, Manuel Lutz, Norman Gercke, Elvira Matthäi, Kari Hemminki, Asta Försti, Matthias Schlesner, Nagarajan Paramasivam, Detlef K Bartsch
J Pers Med. 2021 Jul 2;11(7):631. doi: 10.3390/jpm11070631 https://doi.org/10.3390/jpm11070631

The German National Case Collection for Familial Pancreatic Carcinoma (FaPaCa)—Knowledge Gained in 20 Years
Detlef Klaus Bartsch, Elvira Matthäi, Ioannis Mintziras, Christian Bauer, Jens Figiel, Mercede Sina-Boemers, Thomas M Gress, Peter Langer, Emily P Slater 

Dtsch Arztebl Int. 2021 Mar 12;118(10):163-8. doi: 10.3238/arztebl.m2021.0004  https://doi.org/10.3238/arztebl.m2021.0004

Management of patients with increased risk for familial pancreatic cancer: updated recommendations from the International Cancer of the Pancreas Screening (CAPS) Consortium
Michael Goggins, Kasper Alexander Overbeek, Randall Brand, Sapna Syngal, Marco Del Chiaro, Detlef K Bartsch, Claudio Bassi, Alfredo Carrato, James Farrell, Elliot K Fishman, Paul Fockens, Thomas M Gress, Jeanin E van Hooft, R H Hruban, Fay Kastrinos, Allison Klein, Anne Marie Lennon, Aimee Lucas, Walter Park, Anil Rustgi, Diane Simeone, Elena Stoffel, Hans F A Vasen, Djuna L Cahen, Marcia Irene Canto, Marco Bruno; International Cancer of the Pancreas Screening (CAPS) consortium

Gut. 2020 Jan;69(1):7-17. doi: 10.1136/gutjnl-2019-319352. Epub 2019 Oct 31.https://doi.org/10.1136/gutjnl-2019-319352

German National Case Collection for familial pancreatic Cancer (FaPaCa) - acceptance and psychological aspects of a pancreatic cancer screening program
Frederike S Franke, Elvira Matthäi, Emily P Slater, Christoph Schicker, Johannes Kruse, Detlef K Bartsch

Hered Cancer Clin Pract. 2018 Nov 29:16:17. doi: 10.1186/s13053-018-0100-6. eCollection 2018.https://doi.org/10.1186/s13053-018-0100-6

The Combination of MiRNA-196b, LCN2, and TIMP1 is a Potential Set of Circulating Biomarkers for Screening Individuals at Risk for Familial Pancreatic Cancer
Detlef K Bartsch, Norman Gercke, Konstantin Strauch, Ronja Wieboldt, Elvira Matthäi, Vinona Wagner, Susanne Rospleszcz, Agnes Schäfer, Frederike S Franke, Ioannis Mintziras, Christian Bauer, Tobias Grote, Jens Figiel, Pietro Di Fazio, Andreas Burchert, Silke Reinartz, Elke Pogge von Strandmann, Günter Klöppel, Emily P Slater

J Clin Med. 2018 Sep 20;7(10):295. doi: 10.3390/jcm7100295.https://doi.org/10.3390/jcm7100295

Refinement of screening for familial pancreatic cancer.
Bartsch DK, Slater EP, Carrato A, Ibrahim IS, Guillen-Ponce C, Vasen HF, Matthäi E, Earl J, Jendryschek FS, Figiel J, Steinkamp M, Ramaswamy A, Vázquez-Sequeiros E, Muñoz-Beltran M, Montans J, Mocci E, Bonsing BA, Wasser M, Klöppel G, Langer P, Fendrich V, Gress TM.
Gut. 2016 Aug;65(8):1314~21. doi: 10.1136/gutjnl-2015- 311098. Epub 2016 May 24.https://doi.org/10.1136/gutjnl-2015-311098

Benefit of Surveillance for Pancreatic Cancer in High-Risk Individuals: Outcome of Long-Term Prospective Follow-Up Studies From Three European Expert Centers.
Vasen H, Ibrahim I, Ponce CG, Slater EP, Matthäi E, Carrato A, Earl J, Robbers K, van Mil AM2, Potjer T, Bonsing BA, de Vos Tot Nederveen Cappel WH, Bergman W, Wasser M, Morreau H, Klöppel G, Schicker C, Steinkamp M, Figiel J, Esposito I, Mocci E, Vázquez-Sequeiros E, Sanjuanbenito A, Munoz- Beltran M, Montans J, Langer P, Fendrich V, Bartsch DK.
J Clin Oncol. 2016 Jun 10;34(17):2010-2019. doi: 10.1200/JC0.2015.64.0730. Epub 2016 Apr 25.https://doi.org/10.1200/jco.2015.64.0730

Familial Pancreatic Cancer: To Screen or not to Screen.
Vasen HF, Bartsch DK
EBioMedicine 2:1858-1859 (2015) https://doi.org/10.1016/j.ebiom.2015.12.014

Limited resection of pancreatic cancer in high-riskpatients can result in a secondprimary.
Potjer TP, Bartsch DK, Slater EP, Matthäi E, Bonsing BA, Vasen HF.
Gut 2015;64(8): 1342-4. doi: 10.1136/gutjnl-2015-309568. Epub 2015 Apr 2.https://doi.org/10.1136/gutjnl-2015-309568

MicroRNAs 196a and 196b as potential biomarkers for the early detection of familial pancreatic cancer.
Slater EP, Strauch K, Rospleszcz S, Ramaswamy A, Esposito I, Klöppel G, Matthäi E, Heeger K, Fendrich V, Langer P, Bartsch DK.
Transl Oncol 2014;7(4):464-71.https://doi.org/10.1016/j.tranon.2014.05.007

LCN2 and TIMP1 as potential serum markers for the early detection of familial pancreatic cancer
Slater EP, Fendrich V, Strauch K, Rospleszcz S, Ramaswamy A, Matthäi E, Chaloupka B, Gress TM, Langer P, Bartsch DK.
Transl Oncol 2013; 6:99-103.https://doi.org/10.1593/tlo.12373

Multiple small "imaging" branch-duct type intraductal papillary mucinous neoplasms (IPMNs) in familial pancreatic cancer: indicator for concomitant high grade pancreatic intraepithelial neoplasia?
Bartsch DK, Dietzel K, Bargello M, Matthaei E, Klöppel G, Esposito I, Heverhagen JT, Gress TM, Slater EP, Langer P.
Fam Cancer 2013; 12:89-96.https://doi.org/10.1007/s10689-012-9582-y

Variation in Precursor Lesions of Pancreatic Cancer among High-Risk Groups.
Potjer TP, Schot I, Langer P, Heverhagen JT, Wasser MN, Slater EP, Klöppel G, Morreau HM, Bonsing BA, de Vos Tot Nederveen Cappel WH, Bargello M, Gress TM, Vasen HF, Bartsch DK; on behalf of the Leiden Familial Pancreatic Cancer Group and the FaPaCa registry.
Clin Cancer Res. 2013; 19:442-449.https://doi.org/10.1158/1078-0432.ccr-12-2730

Familial pancreatic cancer- current knowledge
Bartsch DK, Gress TM, Langer P.
Nat Rev Gastroenterol Hepatol 2012; 9:445-453.https://doi.org/10.1038/nrgastro.2012.111

Origin of pancreatic ductal adenocarcinoma from atypical flat lesions: a comparative study in transgenic mice and human tissues.
Aichler M, Seiler C, Tost M, Siveke J, Mazur PK, Da Silva-Buttkus P, Bartsch DK, Langer P, Chiblak S, Dürr A, Höfler H, Klöppel G, Müller-Decker K, Brielmeier M, Esposito I.
J Pathol 2012; 226:723-734.https://doi.org/10.1002/path.3017

Inactivation of Brca2 cooperates with Trp53R172H to induce invasive pancreatic ductal adenocarcinomas in mice: A mouse model of familial pancreatic cancer.
Feldmann G, Karikari C, dal Molin M, Duringer S, Volkmann P, Bartsch DK, Bisht S, Koorstra JB, Brossart P, Maitra A, Fendrich V.
Cancer Biol Ther 2011; 11:959-968.https://doi.org/10.4161/cbt.11.11.15534

German national case collection for familial pancreatic cancer (FaPaCa): ten years experience.
Schneider R, Slater EP, Sina M, Habbe N, Fendrich V, Matthäi E, Langer P, Bartsch DK.
Fam Cancer 2011; 10(2):323-30 Epub 2011 Jan 5https://doi.org/10.1007/s10689-010-9414-x.

The Angiotensin-I-converting Enzyme Inhibitor Enalapril and Aspirin delay progression of Pancreatic Intraepithelial Neoplasia and cancer formation in a genetically engineered mouse model of pancreatic cancer.
Fendrich V, Chen NM, Neef M, Waldmann J, Bucholz M, Feldmann G, Slater EP, Maitra A, Bartsch DK.
Gut. 2010 May;59(5):630-7. Epub 2009 Nov 1.https://doi.org/10.1136/gut.2009.188961

PALB2 mutations in European familial pancreatic cancer families.
Slater EP, Langer P, Niemczyk E, Strauch K, Butler J, Habbe N, Neoptolemos J, Greenhalf W, Bartsch DK. 2010.
Clin Genet. 78(5):490-4 Epub 2010 Mar 18.https://doi.org/10.1111/j.1399-0004.2010.01425.x

Prevalence of BRCA2 and CDKN2a mutations in German familial pancreatic cancer families.
Slater EP, Langer P, Fendrich V, Habbe N, Chaloupka B, Matthäi E, Sina M, Hahn SA, Bartsch DK. 2010.
Fam Cancer. 9(3):335-43 Epub 2010 Feb 27.https://doi.org/10.1007/s10689-010-9329-6

Clinical and genetic analysis of 18 Pancreatic Carcinoma/Melanoma-Prone Families.
Bartsch DK, Langer P, Habbe N, Matthäi E, Chaloupka B, Sina M, Hahn SA, Slater EP. 2010.
Clin Genet 77(4):333-341 Epub 2009 Dec 22.https://doi.org/10.1111/j.1399-0004.2009.01352.x

Five years of prospective screening of high-risk individuals from families with familial pancreatic cancer.
Langer P, Kann PH, Fendrich V, Habbe N, Schneider M, Sina M, Slater EP, Heverhagen JT, Gress TM, Rothmund M, Bartsch DK.
Gut. 2009 Oct;58(10): 1321-2.https://doi.org/10.1136/gut.2008.171611

5 Years of Prospective Screening of High Risk Individuals from Familial Pancreatic Cancer - Families.
Langer P, Kann PH, Fendrich V, Habbe N, Schneider M, Sina M, Slater EP, Heverhagen JT, Gress TM, Rothmund M, Bartsch DK
Gut. 2009 May 25.

Hereditäres Pankreaskazinom
Habbe N, Langer P, Bartsch DK.
Chirurg. 2008 Nov; 79(11):1029-37.https://doi.org/10.1007/s00104-008-1559-x

Palladin Mutation Causes Familial Pancreatic Cancer: Absence in European Families.
Slater E, Amrillaeva V, Fendrich V, Bartsch D, Earl J, Vitone LJ, Neoptolemos JP, Greenhalf W.
PLoS Med 2007; 4(4): e164.https://doi.org/10.1371/journal.pmed.0040164

Evaluation of the 4q32-34 locus in European familial pancreatic cancer.
Earl J, Yan L, Vitone LJ, Risk J, Kemp SJ, McFaul C, Neoptolemos JP, Greenhalf W; European Registry of Hereditary Pancreatitis and Familial Pancreatic Cancer, Kress R, Sina-Frey M, Hahn SA, Rieder H, Bartsch DK; German National Case Collection for Familial Pancreatic Cancer.
Cancer Epidemiol Biomarkers Prev. 2006 Oct; 15(10):1948-55.https://doi.org/10.1158/1055-9965.epi-06-0376

Low frequency of CHEK2 mutations in familial pancreatic cancer.
Bartsch DK, Krysewski K, Sina-Frey M, Fendrich V, Rieder H, Langer P, Kress R, Schneider M, Hahn SA, Slater EP.
Fam Cancer. 2006; 5(4):305-8.https://doi.org/10.1007/s10689-006-7850-4

Familial pancreatic cancer syndromes.
Habbe N, Langer P, Sina-Frey M, Bartsch DK.
Endocrinol Metab Clin North Am. 2006 Jun;35(2):417-30, xi. Review.https://doi.org/10.1016/j.ecl.2006.02.016

Prophylaktische Pankreaschirurgie
Langer P, Rothmund M, Bartsch DK.
Chirurg. 2006 Jan; 77(1):25-32. Review. Germanhttps://doi.org/10.1007/s00104-005-1113-z

Anticipation in familial pancreatic cancer.
McFaul CD, Greenhalf W, Earl J, Howes N, Neoptolemos JP, Kress R, Sina-Frey M, Rieder H, Hahn S, Bartsch DK; European Registry of Hereditary Pancreatitis and Familial Pancreatic Cancer (EUROPAC); German National Case Collection for Familial Pancreatic Cancer (FaPaCa).
Gut. 2006 Feb; 55(2):252-8. Epub 2005 Jun 21.https://doi.org/10.1136/gut.2005.065045

RNASEL germline variants are associated with pancreatic cancer.
Bartsch DK, Fendrich V, Slater EP, Sina-Frey M, Rieder H, Greenhalf W, Chaloupka B, Hahn SA, Neoptolemos JP, Kress R.
Int J Cancer. 2005 Dec 10; 117(5):718-22.https://doi.org/10.1002/ijc.21254

Genetics of hereditary pancreatic carcinoma.
Hahn SA, Bartsch DK.
Clin Lab Med. 2005 Mar; 25(1):117-33. Review.https://doi.org/10.1016/j.cll.2004.12.008

Genetics of hereditary pancreatic carcinoma.
Hahn SA, Bartsch DK.
Gastroenterol Clin North Am. 2004 Dec; 33(4):919-34, ix. Review.https://doi.org/10.1016/j.gtc.2004.07.006

No evidence for germline mutations of the LKB1/STK11 gene in familial pancreatic carcinoma.
Grützmann R, McFaul C, Bartsch DK, Sina-Frey M, Rieder H, Koch R, McCarthy E, Greenhalf W, Neoptolemos JP, Saeger HD, Pilarsky C.
Cancer Lett. 2004 Oct 8; 214(1):63-8.https://doi.org/10.1016/j.canlet.2004.06.012

Prevalence of familial pancreatic cancer in Germany.
Bartsch DK, Kress R, Sina-Frey M, Grützmann R, Gerdes B, Pilarsky C, Heise JW, Schulte KM, Colombo-Benkmann M, Schleicher C, Witzigmann H, Pridöhl O, Ghadimi MB, Horstmann O, von Bernstorff W, Jochimsen L, Schmidt J, Eisold S, Estévéz-Schwarz L, Hahn SA, Schulmann K, Böck W, Gress TM, Zügel N, Breitschaft K, Prenzel K, Messmann H, Endlicher E, Schneider M, Ziegler A, Schmiegel W, Schäfer H, Rothmund M, Rieder H.
Int J Cancer. 2004 Jul 20; 110(6):902-6.https://doi.org/10.1002/ijc.20210

Familial pancreatic cancer.
Rieder H, Bartsch DK.
Fam Cancer. 2004; 3(1):69-74. Review.https://doi.org/10.1023/b:fame.0000026822.67291.a1

NOD3020insC mutation and the risk of familial pancreatic cancer.
Nej K, Bartsch DK, Sina-Frey M, Rieder H, Hahn SA, Lubinski J.
The Hered Cancer Clin Pract 2: (2004)149-150.https://doi.org/10.1186/1897-4287-2-3-149

BRCA2 germline mutations in familial pancreatic carcinoma.
Hahn SA, Greenhalf B, Ellis I, Sina-Frey M, Rieder H, Korte B, Gerdes B, Kress R, Ziegler A, Raeburn JA, Campra D, Grützmann R, Rehder H, Rothmund M, Schmiegel W, Neoptolemos JP, Bartsch DK.
J Natl Cancer Inst. 2003 Feb 5; 95(3):214-21https://doi.org/10.1093/jnci/95.3.214

Pancreatic cancer and basal-cell carcinoma.
Sina-Frey M, Bartsch DK, Grundei T, Grützmann R, Rieder H.
Lancet. 2003 Jan 11; 361(9352):180.https://doi.org/10.1016/s0140-6736(03)12217-9

CDKN2A germline mutations in familial pancreatic cancer.
Bartsch DK, Sina-Frey M, Lang S, Wild A, Gerdes B, Barth P, Kress R, Grützmann R, Colombo-Benkmann M, Ziegler A, Hahn SA, Rothmund M, Rieder H.
Ann Surg. 2002 Dec; 236(6):730-7.https://doi.org/10.1097/00000658-200212000-00005

German national case collection of familial pancreatic cancer - clinical-genetic analysis of the first 21 families.
Rieder H, Sina-Frey M, Ziegler A, Hahn SA, Przypadlo E, Kress R, Gerdes B, Colombo Benkmann M, Eberl T, Grützmann R, Lörken M, Schmidt J, Bartsch DK.
Onkologie. 2002 Jun; 25(3):262-6.https://doi.org/10.1159/000064320

Familial pancreatic cancer--concept for study of the National Case Collection and early diagnosis program for high risk people.
Gerdes B, Kress R, Rieder H, Sina-Frey M, Przypadlo E, Barth P, Rehder H, Hahn SA, Schmiegel W, Rothmund M, Ziegler A, Bartsch DK.
Z Arztl Fortbild Qualitatssich. 2002 May; 96(4):251-5.

Update of familial pancreatic cancer in Germany.
Bartsch DK, Sina-Frey M, Ziegler A, Hahn SA, Przypadlo E, Kress R, Gerdes B, Rieder H.
Pancreatology. 2001; 1(5):510-6.https://doi.org/10.1159/000055853