Publications

Khatri R, Hussmann B, Rawat D, Gürol AO, Linn T.
Intraportal Transplantation of Pancreatic Islets in Mouse Model.
J Vis Exp. 2018 May 5;(135). doi: 10.3791/57559.

Steinfeld K, Beyer D, Mühlfeld C, Mietens A, Eichner G, Altinkilic B, Kampschulte M, Jiang Q, Krombach GA, Linn T, Weidner W, Middendorff R.
Low testosterone in ApoE/LDL receptor double-knockout mice is associated with rarefied testicular capillaries together with fewer and smaller Leydig cells.
Sci Rep. 2018 Apr 3;8(1):5424. doi: 10.1038/s41598-018-23631-9.

Petry SF, Sun LM, Knapp A, Reinl S, Linn T.
Distinct Shift in Beta-Cell Glutaredoxin 5 Expression Is Mediated by Hypoxia and Lipotoxicity Both In Vivo and In Vitro.
Front Endocrinol (Lausanne). 2018 Mar 12;9:84. doi: 10.3389/fendo.2018.00084. eCollection 2018.

Maresch CC, Stute DC, Alves MG, Oliveira PF, de Kretser DM, Linn T.
Diabetes-induced hyperglycemia impairs male reproductive function: a systematic review.
Hum Reprod Update. 2018 Jan 1;24(1):86-105. doi: 10.1093/humupd/dmx033. Review.

Petry SF, Sharifpanah F, Sauer H, Linn T.
Differential expression of islet glutaredoxin 1 and 5 with high reactive oxygen species production in a mouse model of diabesity.
PLoS One. 2017 May 24;12(5):e0176267. doi: 10.1371/journal.pone.0176267. eCollection 2017.

Maresch CC, Petry SF, Theis S, Bosy-Westphal A, Linn T.
Low Glycemic Index Prototype Isomaltulose-Update of Clinical Trials.
Nutrients. 2017 Apr 13;9(4). pii: E381. doi: 10.3390/nu9040381. Review.

Friedrichs P, Schlotterer A, Sticht C, Kolibabka M, Wohlfart P, Dietrich A, Linn T, Molema G, Hammes HP.
Hyperglycaemic memory affects the neurovascular unit of the retina in a diabetic mouse model.
Diabetologia. 2017 Jul;60(7):1354-1358. doi: 10.1007/s00125-017-4254-y. Epub 2017 Mar 20.

Maresch CC, Stute DC, Ludlow H, Hammes HP, de Kretser DM, Hedger MP, Linn T.
Hyperglycemia is associated with reduced testicular function and activin dysregulation in the Ins2Akita+/- mouse model of type 1 diabetes.
Mol Cell Endocrinol. 2017 May 5;446:91-101. doi: 10.1016/j.mce.2017.02.020. Epub 2017 Feb 16.

Pilatz A, Hudemann C, Wolf J, Halefeld I, Paradowska-Dogan A, Schuppe HC, Hossain H, Jiang Q, Schultheiss D, Renz H, Weidner W, Wagenlehner F, Linn T.
Metabolic syndrome and the seminal cytokine network in morbidly obese males.
Andrology. 2017 Jan;5(1):23-30. doi: 10.1111/andr.12296. Epub 2016 Nov 3.

Rekittke NE, Ang M, Rawat D, Khatri R, Linn T.
Regenerative Therapy of Type 1 Diabetes Mellitus: From Pancreatic Islet Transplantation to Mesenchymal Stem Cells.
Stem Cells Int. 2016;2016:3764681. doi: 10.1155/2016/3764681. Epub 2016 Mar 7. Review.

Fehrendt H, Linn T, Hartmann S, Szalay G, Heiss C, Schnettler R, Lips KS.
Negative influence of a long-term high-fat diet on murine bone architecture.
Int J Endocrinol. 2014;2014:318924. doi: 10.1155/2014/318924. Epub 2014 Feb 20.

Padmasekar M, Lingwal N, Samikannu B, Chen C, Sauer H, Linn T.
Exendin-4 protects hypoxic islets from oxidative stress and improves islet transplantation outcome.
Endocrinology. 2013 Apr;154(4):1424-33. doi: 10.1210/en.2012-1983. Epub  2013 Mar 7. PubMed PMID: 23471218.

Blum NM, Mueller K, Lippmann D, Metges CC, Linn T, Pallauf J, Mueller AS.
Feeding of selenium alone or in combination with glucoraphanin differentially affects intestinal and hepatic antioxidant and phase II enzymes in growing rats.
Biol Trace Elem Res. 2013 Mar;151(3):384-99. doi: 10.1007/s12011-012-9567-6. Epub 2012 Dec 29. PubMed PMID: 23271678.

Samikannu B, Chen C, Lingwal N, Padmasekar M, Engel FB, Linn T.
Dipeptidyl peptidase IV inhibition activates CREB and improves islet vascularization through VEGF-A/VEGFR-2 signaling pathway.
PLoS One. 2013 Dec 11;8(12):e82639. doi: 10.1371/journal.pone.0082639. eCollection 2013.

Jiang X, Qian T, Linn T, Cao L, Xiang G, Wang Y, Peng H, Xue P, Zhang L, Chen D, Yang X.
Islet isolation and purification from inbred Wuzhishan miniature pigs.
Xenotransplantation. 2012 May-Jun;19(3):159-65. doi: 10.1111/j.1399-3089.2012.00702.x. PubMed PMID: 22702467.

Lingwal N, Padmasekar M, Samikannu B, Bretzel RG, Preissner KT, Linn T.
Inhibition of gelatinase B (matrix metalloprotease-9) activity reduces cellular inflammation and restores function of transplanted pancreatic islets. 
Diabetes. 2012 Aug;61(8):2045-53. doi: 10.2337/db11-1143. Epub 2012 May 14. PubMed PMID: 22586582; PubMed Central PMCID: PMC3402316.

Blum NM, Mueller K, Hirche F, Lippmann D, Most E, Pallauf J, Linn T, Mueller AS. 
Glucoraphanin does not reduce plasma homocysteine in rats with sufficient Se supply via the induction of liver ARE-regulated glutathione biosynthesis enzymes.
Food Funct. 2011 Nov;2(11):654-64. doi: 10.1039/c1fo10122f. Epub 2011 Sep 29. PubMed PMID: 21959850.

Chen C, Moreno R, Samikannu B, Bretzel RG, Schmitz ML, Linn T.
Improved intraportal islet transplantation outcome by systemic IKK-beta inhibition: NF-κB  activity in pancreatic islets depends on oxygen availability. 
Am J Transplant. 2011 Feb;11(2):215-24. doi: 10.1111/j.1600-6143.2010.03390.x. Epub 2011 Jan 10. PubMed PMID: 21219576.

Lai Y, Brandhorst H, Hossain H, Bierhaus A, Chen C, Bretzel RG, Linn T.
Activation of NFκB dependent apoptotic pathway in pancreatic islet cells by hypoxia.
Islets. 2009 Jul-Aug;1(1):19-25. doi: 10.4161/isl.1.1.8530. PubMed PMID: 21084845.

Chandrasekar MP, Sauer H, Linn T.
The role of AMP Kinase on the beta-cell differentiation of mouse embryonic stem cells.
J Stem Cells Regen Med. 2010 Oct 23;6(2):55. eCollection 2010. No abstract available.

Chen C, Kuehn C, Bretzel RG, Linn T. 
Anti-inflammatory thalidomide improves islet grafts survival and functions in a xenogenic environment
PLoS One. 2009 Jul 20;4(7):e6312. doi: 10.1371/journal.pone.0006312. Erratum in: PLoS One. 2009;4(11). doi: 10.1371/annotation/be980555-eeb9-4c0e-91f9-cdc1d8f2709b. PubMed PMID: 19617916; PubMed Central PMCID: PMC2708353.

Lai Y, Chen C, Linn T.
Innate immunity and heat shock response in islet transplantation. 
Clin Exp Immunol. 2009 Jul;157(1):1-8. doi: 10.1111/j.1365-2249.2009.03899.x. Epub 2009 Feb 4. Review. PubMed PMID: 19302242; PubMed Central PMCID: PMC2710586.

Lai Y, Drobinskaya I, Kolossov E, Chen C, Linn T.
Genetic modification of cells for transplantation.
Adv Drug Deliv Rev. 2008 Jan 14;60(2):146-59. Epub 2007 Oct 18. Review.

Drobinskaya I, Linn T, Saric T, Bretzel RG, Bohlen H, Hescheler J, Kolossov E. 
Scalable selection of hepatocyte- and hepatocyte precursor-like cells from culture of differentiating transgenically modified murine embryonic stem cells.
Stem Cells. 2008 Sep;26(9):2245-56. doi: 10.1634/stemcells.2008-0387. Epub 2008 Jun 12. PubMed PMID: 18556507.

Kidszun A, Schneider D, Erb D, Hertl G, Schmidt V, Eckhard M, Preissner KT, Breier G, Bretzel RG, Linn T.
Isolated pancreatic islets in three-dimensional matrices are responsive to stimulators and inhibitors of angiogenesis.
Cell Transplant. 2006;15(6):489-97.

Linn T, Schmitz J, Hauck-Schmalenberger I, Lai Y, Bretzel RG, Brandhorst H, Brandhorst D.
Ischaemia is linked to inflammation and induction of angiogenesis in pancreatic islets.
Clin Exp Immunol. 2006 May;144(2):179-87. Review.